Welcome to HepaPredict AB

Physiological hepatic in vitro systems for improved prediction of drug response and safety

We are a specialized CRO, focussing on drug metabolism, toxicity, and drug development for liver disease utilizing our advanced 3D primary human liver culture platform.

Our Services

Service philosophy: Delivering the best science by keeping things:

“As simple as possible and as complex as necessary.”

Advantages of the HepaPredict System

Our 3D spheroid platform offers multiple advantages over alternative in vitro systems and animal models:

  • Physiologically replicative in vitro system with close resemblance to human liver on transcriptomic, proteomic and metabolomic level.

  • Optimized to support co-cultures with non-parenchymal cells, such as Kupffer, biliary and Stellate cells.

  • Functionally stable and suitable for chronic applications, thus allowing to assess long-term toxicity, pharmacokinetics, and chronic drug response, not supported by conventional in vitro systems.

  • Easy manipulation of gene expression through knockdown or knockin techniques.

  • Emulation of human inter-individual variability in an in vitro setting.

  • High-throughput compatibility and scalability allows screening of hundreds of conditions and/or drug candidates with multiple replicates, adding to statistical power.

  • Controlled, chemically defined experimental conditions ensure maximal reproducibility.

  • Direct translation of findings to patients by using patient-derived cells instead of cell lines or animal models.

Let’s Work Together